Abstract摘要
连续流动化学是近十年来发展起来的一种新的和潜在的技术。该项技术的突出特点是安全性高、传热传质速度快，全过程可通过自动编程和在线实时监测实现。因此，连续流动技术提供了更好的改进方式和反应广泛应用于有机合成和药物。本试验的目的是在连续流动技术原理进行综合概述和评价其优劣的连续流动过程。并介绍了近年来这一技术在有机药物合成化学中的各种应用。合成化学的未来可能依赖于连续流技术的发展。Continuous flow chemistry is a new andmost potential technology developed in the recent ten years. The outstanding properties of this technology are its high safety performance and remarkably speed of heat and mass transmission.The whole process can be achieved by automatic programs and monitored on line real-time. Thus, the continuous flow technology offers animproved way to perform better reactions and widely apply in organic and drug synthesis. The aim of this assay is to give acomprehensive overview on the principlesof continuous flow technology and evaluate its pros and cons of the continuous flow processes. And the assay also introduce the various applications of this technology in the organic drug synthetic chemistry recently. The future of synthetic chemistry might rely on the development of continuous flow technology.
TEXT文本
有效的合成化学对制药行业非常重要。 以前的工业过程如有机分子生产大多在间歇反应堆中进行。 然而，间歇式反应堆的化学生产并不是选择性，安全性和可管理性。 制药行业在过去几年中一直在适应改变其方法和策略，可以改善有效药物合成的更好解决方案。近十年来，连续流合成已经成为显着改善的最有潜力的技术之一 对制药工艺的影响。Effective synthetic chemistry is very important for the pharmaceutical industry. The previousindustrial processes such as organic molecular’ production are mostly carried out in batch reactors. However, the chemical production in batch reactors are not selectivity, safety and manageable. The pharmaceutical industry has been adapting to change its approaches and strategies in the past few years that it can improve better solutions for effective drug synthesis.In the recent ten years, the continuous flow synthesis is emerging as one of the most potential techniques to significantly improve and impact on the pharmaceutical processes.
Introduction (100)
Principles of continuous flow and microreactors (700)
-Jas et al 2003
-Fletcher 2002
-hartman 2009
Analysis of pros and cons of the technology (700)
-lab on a chip
-Wegner 2011
Applications in organic/drug synthesis(1200)
-Gutmann et al 2015-many
-Snead et al 2015
-watts and willis 2013-many
-pellegati 2002
-brittong 2015
-deng et al 2015
-Kundu 2011
Conclusion (300)
-Challenges- Wiles and watts 2012
Reference
Conclusion:
The aim of this assay is to give acomprehensive overview on the principles of continuous flow technology and evaluate its pros and cons of the continuous flow processes. The continuous flow system is mainly consist of two parts: the micro reactors and pumps. The fabrication and characterization of micro reactors will depend on the material used for channel network.The whole reaction process can be achieved by automatic computer programs and monitored on line real-time. The outstanding properties of this technology are its high safety performance and remarkably speed of heat and mass transmission. And there are also some disadvantages in the continuous flow system, such as expensive materials, suffering from restricted fluid flow capacity and high pressure drop. Recently, the continuous flow technology offers animproved way to perform better reactions and widely apply in organicmolecular and drug synthesis. In reactions of all multiple phases, the continuous flow technology will offer great temperature control, high yields of production and less wastes. As a result, it is very clear that the synthetic chemistry will benefit from the development of the continuous flow technology. And it also require more optimization step to transfer the continuous flow system from laboratorial scale to industrial scale in the organic and pharmaceutical industry.
