目 录
一、中文摘要…………………………………………………………………………1
二、英文摘要…………………………………………………………………………3
三、符号说明…………………………………………………………………………5
四、正 文
（一）前 言………………………………………………………………………6
（二）材料和方法………………………………………………………………7
（三）结 果……………………………………………………………………10
（四）讨 论……………………………………………………………………12
（五）结 论……………………………………………………………………29
五、附图表………………………………………………………………………30
六、参考文献………………………………………………………………………37
七、文献综述………………………………………………………………………42
八、致 谢……………………………………………………………………………50
九、攻读学位期间撰写的论文……………………………………………………51
十、学位论文原创性声明及使用授权声明………………………………………52
HIF-1α、VEGF、uPA在胶质瘤中的表达
及其与血管生成的关系
研 究 生：
专 业：
导 师：
中文摘要
THE EXPRESSION OF HIF-1α，VEGF AND UPA IN
GLIOMAS ANDTHE RELATION WITH ANGIOGENESIS
Postgraduate
Speciality
Supervisor Professor
Professor
ABSTRACT
符 号 说 明
英文缩写 英文全称 中文全称
前 言
材料与方法
结 果
讨 论
结 论
附 图 表
参考文献
[1] 王忠诚主编．神经外科学[M]．第一版，武汉：湖北科学技术出版社, 1998: 397-399.
[2] Zetter BR.Angiogenesis and tumor metastasis[J].Ann Rev Med,1998,49,407-414.
[3]Zagzag D, Friedlander DR, MargolisB et al. Molecular evens implicated in brain tumor angiogenesis and invasion [J].Pediatr Neurosurg 2000,33(1):49-55.
[4] Zhong H, De Marzo AM, Laughner E. Overexlmession of hypoxia-inducible factor lalpha in common human cancers and theirmetastases[J].Cancer.1999.59: 5830-5835.
[5] Zagag D, Zhong H, Scalziti JM. Exorosion of hvooxia-inducible factor 1 alpha in brain tumors association with anmo Qenests-invision and progression[J]. Cancer. 2000.88: 26-28.
[6] 许良中,杨文涛.免疫组织化学反应结果的判断标准[J]. 中国癌症杂志，1996, (4): 29-31.
[7]Bergers G, Benjamin LE. Tumor igenesis and the angiogenic switch[J]. Nat Rev Cancer, 2003, 3(6): 401-410.
[8]Zhang X, Yamashita M, Uetsuki H, et al. Angiogenesis in renal cell carcinoma: Evaluation of microvessel density, vascular endothelial growth factor and matrix metalloproteinases[J]. Int J Urol, 2002,9(9): 509-514.
[9]Konno H, Baba M, Shoji T, et al. Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer[J]. Clin Exp Metastasis, 2002,19(6): 527-534.
[10] Maniotis AJ, Folberg R, Hess A, et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry[J]. Am J Pathol, 1999, 155(3): 739-752.
[11]Robert F, May J, Hendrix C. Maniotis: Vasculogenic Mimicry and Tumor Angio- genesis [J]. Am J Pathol,2000,156(2): 361-381.
[12]Angela RH, Elisabeth AS, Lynn MG, et al. Molecular Regulation of Tumor Cell Vasculogenic Mimicry by Tyrosine Phosphorylation: Role of Epithelial Cell Kinase (Eck/EphA2)[J]. CancerRes,2001,61:3250-3255.
[13]Brekken RA, Overholser JP, Stastny VA, et al. Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2(KDR/Flk-2) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice[J]. Cancer Res, 2000, 60(18): 5117- 5124.
[14]McMahon GA, Petitclere E, Stefansson S,et al. Plasminogen activation inhibitor-1 regulates tumor growth and angiogenesis [J]. Biol Chem, 2001, 276(36): 33964-33968.
[15]Cronauer MV, Schulz WA, Seifert HH,et al. Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implications[J]. Eur Urol. 2003, 43(3):309-319.
[16] Birner P, Gatterbauer B, Oberhuber G, et al. Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas:its impact on prognosis and on neoangiogensis [J]. Cancer,2001,92(1): 165.
[17]Zhong H, DeMarzo AM, Laughner E, et al. Overexpression of hypoxia indu- cible factor 1alpha in common human cancers and their metastases[J].Cancer Res,1999,59(22):583.
[18] 高文昌,于如同,潘昕,等.脑胶质瘤HIF-1α、CD34表达与预后的关系[J].实用临床医药杂志,2004,8 [1]:24-26.
[19]郭克勤,于如同,高文昌.HIF-1α、VEGF表达与脑胶质瘤预后的相关性[J].徐州医学院学报, 2003,23(3):228-230.
[20] 朱宏. 缺氧诱导因子与肿瘤血管生成[J].国外医学肿瘤学分册,2004, 31[8]: 24-26.
[21]Korkolopoulou P, Patsouris E, Konstantinidiu AE, et al. Hypoxia-inducible factor 1alpha∕vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry,prolife ration and prognosis[J].Neuropathol Appl Neurobiol. 2004,30(3):267-278.
[22]陈治.缺氧诱导因子-1的研究与应用进展[J].国外医学生理病理科学与临床分册, 2004,24[1]:34-37.
文献综述
致 谢
攻读学位期间撰写的论文
学位论文原创性声明
本人声明，所呈交的学位论文系在导师指导下本人独立完成的研究成果。文中
